PatientSpotlight is built from primary sources. We do not rely on secondary coverage as a substitute for the underlying document. The categories below are the source types we routinely cite — they map directly to the sourceTypes tag on every piece.
Regulatory and reimbursement
- FDA approval letters, prescribing information, and post-marketing requirements
- FDA Peripheral and Central Nervous System Drugs Advisory Committee transcripts and briefing documents
- CMS National Coverage Determinations and registry program documentation
- EMA scientific opinions, authorization decisions, and assessment reports
- NICE technology appraisals and final guidance documents
- MHRA authorizations and assessment summaries
- Other major-market regulators (PMDA, TGA, Health Canada) where relevant
Clinical and scientific
- Peer-reviewed publications of pivotal Alzheimer's trials
- AAIC and CTAD conference proceedings, late-breaking sessions, and abstracts
- Consensus guidance from the Alzheimer's Association, the AAN, and the IWG
- Plasma biomarker validation studies and assay technical documentation
- Tau and amyloid PET imaging validation literature
- ClinicalTrials.gov and equivalent national registries
Industry and pipeline
- Sponsor pipeline disclosures, investor materials, and regulatory submissions
- SEC filings (10-Ks, 10-Qs, 8-Ks) for major Alzheimer's developers
- Company-sponsored data presentations at AAIC, CTAD, and major investor conferences
- Manufacturing and supply-chain disclosures relevant to delivery infrastructure
Real-world evidence and health-system practice
- Published health-system anti-amyloid rollout reports and protocol audits
- Specialty-lab reports on plasma biomarker uptake and performance
- Registry data published or referenced in peer-reviewed venues
- Health-system imaging-capacity and infusion-capacity disclosures
How sources appear in pieces
Every Signal, Insight, Snapshot, and Explained piece carries a "Key sources" section at the bottom. That section names the specific documents the piece relies on — the FDA label, the named NCD, the specific publication. The category-level tags at the top of the piece (for example, FDA · industry-filing · peer-reviewed) summarize the source mix without naming individual documents.
For more on how we use sources and what we will not do with them, see our Methodology and Editorial policy.