PatientSpotlight, by PanaceaIntelPatientSpotlight
SignalApr 30, 20261 min read

Metformin alternatives in prediabetes management

GLP-1 and SGLT2 use in prediabetes is challenging metformin's long-standing first-line position.

Metformin has been the default prediabetes pharmacotherapy for two decades. GLP-1 agonist and SGLT2 inhibitor use in prediabetes is now growing, particularly in patients with cardiovascular or weight-management considerations. Whether this becomes a routine first-line displacement or stays a comorbidity-driven niche depends on guideline body decisions over the next 18 months.

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