Genetically-targeted Parkinson's programs reach pivotal data
LRRK2 inhibitors and GBA-targeted programs in Parkinson's disease are reading out as the first genetically-defined Parkinson's therapy options.
Parkinson's disease has been a dopamine-replacement story for sixty years. LRRK2 inhibitor programs (in patients with LRRK2 mutations and broader populations) and GBA-pathway programs (in patients with GBA-related Parkinson's) are now reaching pivotal trial data. If either succeeds, Parkinson's joins the list of neurology categories with genetically-defined mechanism-targeted commercial models. The genetic-testing infrastructure question is the gating commercial enabler.
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