PatientSpotlight, by PanaceaIntelPatientSpotlight
SignalNEWMay 5, 20261 min read

Glioblastoma therapy options evolve past temozolomide and TTFields

Tumour-treating fields maturity, IDH-mutant glioma vorasidenib approval, and emerging mechanism-targeted programs are reshaping glioma management.

Glioblastoma has been a temozolomide-and-radiation category with tumour-treating fields as the major addition. Vorasidenib (IDH inhibitor) is now approved for IDH-mutant grade 2 glioma, marking the first targeted therapy in adult diffuse glioma. Late-stage programs in glioblastoma (immunotherapy combinations, targeted therapy in molecularly-defined subgroups, novel delivery approaches across the blood-brain barrier) are reading out. The category is structurally evolving for the first time in over a decade.

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